PDBe 1hbt

X-ray diffraction
2Å resolution

Human alpha-thrombin complexed with a peptidyl pyridinium methyl ketone containing bivalent inhibitor

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain Chain: L
Molecule details ›
Chain: L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Thrombin heavy chain Chain: H
Molecule details ›
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
P596 Inhibitor peptide Chain: I
Molecule details ›
Chain: I
Length: 18 amino acids
Theoretical weight: 2.12 KDa

Ligands and Environments

No bound ligands

3 modified residues:

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 70.6Å b: 72.2Å c: 72.8Å
α: 90° β: 100.4° γ: 90°
R-values:
R R work R free
0.181 0.181 not available
Expression system: Not provided