PDBe 1h6e

X-ray diffraction
3.6Å resolution

MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH CTLA-4 INTERNALIZATION PEPTIDE TTGVYVKMPPT

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
AP-2 complex subunit mu Chain: A
Molecule details ›
Chain: A
Length: 288 amino acids
Theoretical weight: 33.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q96CW1 (Residues: 141-435; Coverage: 66%)
  • Best match: Q96CW1-2 (Residues: 162-433)
Gene names: AP2M1, CLAPM1, KIAA0109
Structure domains: Immunoglobulin-like
Cytotoxic T-lymphocyte protein 4 Chain: P
Molecule details ›
Chain: P
Length: 11 amino acids
Theoretical weight: 1.19 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P16410 (Residues: 197-207; Coverage: 6%)
Gene names: CD152, CTLA4

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P64
Unit cell:
a: 126.779Å b: 126.779Å c: 74.161Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.278 0.278 0.317
Expression systems:
  • Escherichia coli BL21
  • Not provided