PDBe 1h15

X-ray diffraction
3.1Å resolution

X-ray crystal structure of HLA-DRA1*0101/DRB5*0101 complexed with a peptide from Epstein Barr Virus DNA polymerase

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 182 amino acids
Theoretical weight: 21.16 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01903 (Residues: 26-207; Coverage: 80%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DR beta 5 chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 190 amino acids
Theoretical weight: 22.23 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q30154 (Residues: 30-219; Coverage: 80%)
Gene name: HLA-DRB5
Sequence domains:
Structure domains:
DNA polymerase catalytic subunit Chains: C, F
Molecule details ›
Chains: C, F
Length: 14 amino acids
Theoretical weight: 1.63 KDa
Source organism: Human gammaherpesvirus 4
Expression system: Not provided
UniProt:
  • Canonical: P03198 (Residues: 628-641; Coverage: 1%)
Gene name: BALF5

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P65
Unit cell:
a: 179.244Å b: 179.244Å c: 92.884Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.256 0.256 0.31
Expression systems:
  • Drosophila melanogaster
  • Not provided