PDBe 1gxd

X-ray diffraction
3.1Å resolution

proMMP-2/TIMP-2 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
72 kDa type IV collagenase Chains: A, B
Molecule details ›
Chains: A, B
Length: 631 amino acids
Theoretical weight: 71 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P08253 (Residues: 30-660; Coverage: 100%)
Gene names: CLG4A, MMP2
Sequence domains:
Structure domains:
Metalloproteinase inhibitor 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 194 amino acids
Theoretical weight: 21.78 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P16035 (Residues: 27-220; Coverage: 100%)
Gene name: TIMP2
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: C2221
Unit cell:
a: 75.696Å b: 374.575Å c: 191Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.278 0.275 0.333
Expression system: Trichoplusia ni