PDBe 1gux

X-ray diffraction
1.85Å resolution

RB POCKET BOUND TO E7 LXCXE MOTIF

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Retinoblastoma-associated protein Chain: A
Molecule details ›
Chain: A
Length: 218 amino acids
Theoretical weight: 25.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: NEW P06400 (Residues: 372-589; Coverage: 24%)
Gene name: RB1
Sequence domains: Retinoblastoma-associated protein A domain
Structure domains: Cyclin-like
Retinoblastoma-associated protein Chain: B
Molecule details ›
Chain: B
Length: 152 amino acids
Theoretical weight: 18.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: NEW P06400 (Residues: 636-787; Coverage: 16%)
Gene name: RB1
Sequence domains: Retinoblastoma-associated protein B domain
Structure domains: Cyclin-like
ONCOPROTEIN Chain: E
Molecule details ›
Chain: E
Length: 9 amino acids
Theoretical weight: 1.16 KDa
Source organism: Human papillomavirus

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: C2
Unit cell:
a: 103.5Å b: 76.8Å c: 64Å
α: 90° β: 90.9° γ: 90°
R-values:
R R work R free
0.218 0.218 0.289
Expression system: Escherichia coli BL21(DE3)