PDBe 1gc1

X-ray diffraction
2.5Å resolution

HIV-1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Surface protein gp120 Chain: G
Molecule details ›
Chain: G
Length: 321 amino acids
Theoretical weight: 35.43 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: NEW P04578 (Residues: 83-127, 195-297, 330-492; Coverage: 38%)
Gene name: env
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
T-cell surface glycoprotein CD4 Chain: C
Molecule details ›
Chain: C
Length: 185 amino acids
Theoretical weight: 20.5 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: NEW P01730 (Residues: 26-210; Coverage: 43%)
Gene name: CD4
Sequence domains: Immunoglobulin C2-set domain
Structure domains: Immunoglobulins
ANTIBODY 17B Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 23.37 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
Structure domains: Immunoglobulins
ANTIBODY 17B Chain: H
Molecule details ›
Chain: H
Length: 229 amino acids
Theoretical weight: 24.48 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P2221
Unit cell:
a: 71.64Å b: 88.13Å c: 196.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.302
Expression systems:
  • Drosophila melanogaster
  • Cricetulus griseus
  • Mus musculus