PDBe 1fyx

X-ray diffraction
2.8Å resolution

CRYSTAL STRUCTURE OF P681H MUTANT OF TIR DOMAIN OF HUMAN TLR2

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll-like receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 149 amino acids
Theoretical weight: 18.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60603 (Residues: 636-784; Coverage: 20%)
Gene names: TIL4, TLR2
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 32-ID
Spacegroup: P6222
Unit cell:
a: 122.1Å b: 122.1Å c: 92.1Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.26 0.242 0.284
Expression system: Escherichia coli