PDBe 1fyh

X-ray diffraction
2.04Å resolution

1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interferon gamma Chains: A, D
Molecule details ›
Chains: A, D
Length: 258 amino acids
Theoretical weight: 30.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01579 (Residues: 24-143, 28-156; Coverage: 93%)
Gene name: IFNG
Structure domains: Growth Hormone; Chain: A;
Interferon gamma receptor 1 Chains: B, E
Molecule details ›
Chains: B, E
Length: 229 amino acids
Theoretical weight: 25.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15260 (Residues: 18-246; Coverage: 49%)
Gene name: IFNGR1
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 72.94Å b: 107.6Å c: 85.08Å
α: 90° β: 97.94° γ: 90°
R-values:
R R work R free
0.241 0.194 0.246
Expression system: Escherichia coli