PDBe 1fll

X-ray diffraction
3.5Å resolution

MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3

Released:
Source organism: Homo sapiens
Primary publication:
Molecular basis for CD40 signaling mediated by TRAF3.
Proc. Natl. Acad. Sci. U.S.A. 97 10395-9 (2000)
PMID: 10984535

Function and Biology Details

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero hexamer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
TNF receptor-associated factor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 228 amino acids
Theoretical weight: 25.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW Q13114 (Residues: 341-568; Coverage: 40%)
Gene names: CAP1, CRAF1, TRAF3
Structure domains: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Tumor necrosis factor receptor superfamily member 5 Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 21 amino acids
Theoretical weight: 2.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: NEW P25942 (Residues: 246-266; Coverage: 8%)
Gene names: CD40, TNFRSF5

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P321
Unit cell:
a: 83.76Å b: 83.76Å c: 212.57Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.173 0.173 0.312
Expression systems:
  • Escherichia coli
  • Not provided