Function and Biology Details
Reaction catalysed:
Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- WAP-type 'four-disulfide core' domain
- Peptidase S1A, chymotrypsin family
- Serine proteases, trypsin domain
- Elafin-like superfamily
- Peptidase S1, PA clan, chymotrypsin-like fold
- Serine proteases, trypsin family, serine active site
- Serine proteases, trypsin family, histidine active site
- Peptidase S1, PA clan
Structure domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133454 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Chymotrypsin-like elastase family member 1
Molecule details ›
Chain: E
Length: 240 amino acids
Theoretical weight: 25.93 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 240 amino acids
Theoretical weight: 25.93 KDa
Source organism: Sus scrofa
UniProt:
- Canonical:
P00772 (Residues: 27-266; Coverage: 96%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Elafin
Molecule details ›
Chain: I
Length: 57 amino acids
Theoretical weight: 6.01 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains:
Length: 57 amino acids
Theoretical weight: 6.01 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P19957 (Residues: 61-117; Coverage: 60%)
Sequence domains:
- Trappin protein transglutaminase binding domain
- WAP-type (Whey Acidic Protein) 'four-disulfide core'
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Spacegroup:
P21
Expression system: Not provided
