PDBe 1emu

X-ray diffraction
1.9Å resolution

STRUCTURE OF THE AXIN RGS-HOMOLOGOUS DOMAIN IN COMPLEX WITH A SAMP REPEAT FROM APC

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis of the Axin-adenomatous polyposis coli interaction.
EMBO J. 19 2270-9 (2000)
PMID: 10811618

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Axin-1 Chain: A
Molecule details ›
Chain: A
Length: 132 amino acids
Theoretical weight: 15.35 KDa
Source organism: Homo sapiens
Expression system: Bacteria
UniProt:
  • Canonical: O15169 (Residues: 80-211; Coverage: 15%)
Gene names: AXIN, AXIN1
Sequence domains: Regulator of G protein signaling domain
Structure domains:
Adenomatous polyposis coli protein Chain: B
Molecule details ›
Chain: B
Length: 16 amino acids
Theoretical weight: 1.77 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P25054 (Residues: 2034-2049; Coverage: 1%)
Gene names: APC, DP2.5

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P212121
Unit cell:
a: 30.6Å b: 69.98Å c: 71.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.205 0.221
Expression systems:
  • Bacteria
  • Not provided