PDBe 1ejf

X-ray diffraction
2.49Å resolution

CRYSTAL STRUCTURE OF THE HUMAN CO-CHAPERONE P23

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin E synthase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 14.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q15185 (Residues: 1-125; Coverage: 78%)
Gene names: P23, PTGES3, TEBP
Sequence domains: CS domain
Structure domains: Immunoglobulin-like

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P43212
Unit cell:
a: 61.802Å b: 61.802Å c: 162.888Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.236 0.268
Expression system: Escherichia coli BL21