PDBe 1eem

X-ray diffraction
2Å resolution

GLUTATHIONE TRANSFERASE FROM HOMO SAPIENS

Released:

Function and Biology Details

Reactions catalysed:
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate
RX + glutathione = HX + R-S-glutathione
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase omega-1 Chain: A
Molecule details ›
Chain: A
Length: 241 amino acids
Theoretical weight: 27.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P78417 (Residues: 1-241; Coverage: 100%)
Gene names: GSTO1, GSTTLP28
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSH 1 x GSH
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P3121
Unit cell:
a: 57.09Å b: 57.09Å c: 140.28Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.219 0.271
Expression system: Escherichia coli