PDBe 1eb1

X-ray diffraction
1.8Å resolution

Complex structure of human thrombin with N-methyl-arginine inhibitor

Released:

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
PEPTIDE INHIBITOR Chain: A
Molecule details ›
Chain: A
Length: 10 amino acids
Theoretical weight: 1.21 KDa
Source organism: synthetic construct
Expression system: Not provided
Thrombin heavy chain Chain: H
Molecule details ›
Chain: H
Length: 257 amino acids
Theoretical weight: 29.59 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 364-620; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Thrombin light chain Chain: L
Molecule details ›
Chain: L
Length: 27 amino acids
Theoretical weight: 3.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 334-360; Coverage: 5%)
Gene name: F2
3-CYCLOHEXYL-D-ALANYL-L-PROLYL-N~2~-METHYL-L-ARGININE Chain: B
Molecule details ›
Chain: B
Length: 3 amino acids
Theoretical weight: 439 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands

2 modified residues:

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 69.839Å b: 71.508Å c: 71.71Å
α: 90° β: 99.34° γ: 90°
R-values:
R R work R free
0.191 0.191 0.22
Expression system: Not provided