PDBe 1dkf

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF A HETERODIMERIC COMPLEX OF RAR AND RXR LIGAND-BINDING DOMAINS

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoic acid receptor RXR-alpha Chain: A
Molecule details ›
Chain: A
Length: 233 amino acids
Theoretical weight: 25.97 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P28700 (Residues: 230-462; Coverage: 50%)
Gene names: Nr2b1, Rxra
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Retinoic acid receptor alpha Chain: B
Molecule details ›
Chain: B
Length: 235 amino acids
Theoretical weight: 26.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10276 (Residues: 182-416; Coverage: 51%)
Gene names: NR1B1, RARA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14
Spacegroup: P6122
Unit cell:
a: 116.6Å b: 116.6Å c: 207.8Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.203 0.262
Expression system: Escherichia coli