PDBe 1dfp

X-ray diffraction
2.4Å resolution

FACTOR D INHIBITED BY DIISOPROPYL FLUOROPHOSPHATE

Released:
Source organism: Homo sapiens
Primary publication:
Structure of diisopropyl fluorophosphate-inhibited factor D.
Acta Crystallogr. D Biol. Crystallogr. 53 143-50 (1997)
PMID: 15299948

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor D Chains: A, B
Molecule details ›
Chains: A, B
Length: 228 amino acids
Theoretical weight: 24.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00746 (Residues: 26-253; Coverage: 98%)
Gene names: CFD, DF, PFD
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P21
Unit cell:
a: 40.6Å b: 125.7Å c: 41.9Å
α: 90° β: 110.05° γ: 90°
R-values:
R R work R free
0.148 0.148 0.228