PDBe 1de4

X-ray diffraction
2.8Å resolution

HEMOCHROMATOSIS PROTEIN HFE COMPLEXED WITH TRANSFERRIN RECEPTOR

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Hereditary hemochromatosis protein Chains: A, D, G
Molecule details ›
Chains: A, D, G
Length: 275 amino acids
Theoretical weight: 32.34 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q30201 (Residues: 23-297; Coverage: 84%)
Gene names: HFE, HLAH
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, E, H
Molecule details ›
Chains: B, E, H
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Transferrin receptor protein 1, serum form Chains: C, F, I
Molecule details ›
Chains: C, F, I
Length: 640 amino acids
Theoretical weight: 71.81 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P02786 (Residues: 121-760; Coverage: 84%)
Gene name: TFRC
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: C2
Unit cell:
a: 110.4Å b: 144.4Å c: 327.1Å
α: 90° β: 93.6° γ: 90°
R-values:
R R work R free
0.231 0.231 0.265
Expression systems:
  • Cricetulus griseus
  • Trichoplusia ni