PDBe 1cza

X-ray diffraction
1.9Å resolution

MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE, GLUCOSE-6-PHOSPHATE, AND ADP

Released:

Function and Biology Details

Reaction catalysed:
ATP + D-hexose = ADP + D-hexose 6-phosphate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hexokinase-1 Chain: N
Molecule details ›
Chain: N
Length: 917 amino acids
Theoretical weight: 102.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19367 (Residues: 1-917; Coverage: 100%)
Gene name: HK1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P21212
Unit cell:
a: 145.66Å b: 145.8Å c: 58.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.211 0.258
Expression system: Escherichia coli