PDBe 1cee

Solution NMR

SOLUTION STRUCTURE OF CDC42 IN COMPLEX WITH THE GTPASE BINDING DOMAIN OF WASP

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cell division control protein 42 homolog Chain: A
Molecule details ›
Chain: A
Length: 179 amino acids
Theoretical weight: 19.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P60953 (Residues: 1-179; Coverage: 94%)
Gene name: CDC42
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Wiskott-Aldrich syndrome protein Chain: B
Molecule details ›
Chain: B
Length: 59 amino acids
Theoretical weight: 6.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P42768 (Residues: 230-288; Coverage: 12%)
Gene names: IMD2, WAS
Structure domains: SerineThreonine-protein kinase PAK-alpha; Chain A

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING, TORSION ANGLE DYNAMICS
Expression system: Escherichia coli BL21(DE3)