PDBe 1c4y

X-ray diffraction
2.7Å resolution

SELECTIVE NON-ELECTROPHILIC THROMBIN INHIBITORS

Released:
Source organism: Homo sapiens
Primary publication:
Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1.
Acta Crystallogr. D Biol. Crystallogr. 56 294-303 (2000)
PMID: 10713516

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain Chain: 1
Molecule details ›
Chain: 1
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Thrombin heavy chain Chain: 2
Molecule details ›
Chain: 2
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
HIRUGEN Chain: 3
Molecule details ›
Chain: 3
Length: 13 amino acids
Theoretical weight: 1.59 KDa

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Spacegroup: P65
Unit cell:
a: 93.1Å b: 93.1Å c: 95.29Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.144 0.144 not available