PDBe 1bx2

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE OF HLA-DR2 (DRA*0101,DRB1*1501) COMPLEXED WITH A PEPTIDE FROM HUMAN MYELIN BASIC PROTEIN

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero hexamer
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 180 amino acids
Theoretical weight: 20.97 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P01903 (Residues: 27-206; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1-15 beta chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 191 amino acids
Theoretical weight: 22.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01911 (Residues: 32-222; Coverage: 81%)
Gene names: HLA-DRB1, HLA-DRB2
Sequence domains:
Structure domains:
Myelin basic protein Chains: C, F
Molecule details ›
Chains: C, F
Length: 15 amino acids
Theoretical weight: 1.8 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02686 (Residues: 217-231; Coverage: 5%)
Gene name: MBP

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P43212
Unit cell:
a: 95.403Å b: 95.403Å c: 295.219Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.238 0.266
Expression system: unidentified baculovirus