PDBe 1axi

X-ray diffraction
2.1Å resolution

STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE

Released:
Source organism: Homo sapiens
Primary publication:
Structural plasticity in a remodeled protein-protein interface.
Science 278 1125-8 (1997)
PMID: 9353194

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Somatotropin Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 22.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01241 (Residues: 27-217; Coverage: 100%)
Gene name: GH1
Structure domains: Growth Hormone; Chain: A;
Growth hormone-binding protein Chain: B
Molecule details ›
Chain: B
Length: 236 amino acids
Theoretical weight: 27.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10912 (Residues: 19-254; Coverage: 38%)
Gene name: GHR
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P43212
Unit cell:
a: 65.6Å b: 65.6Å c: 231.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 0.262
Expression system: Escherichia coli