PDBe 1awb

X-ray diffraction
2.5Å resolution

HUMAN MYO-INOSITOL MONOPHOSPHATASE IN COMPLEX WITH D-INOSITOL-1-PHOSPHATE AND CALCIUM

Released:

Function and Biology Details

Reactions catalysed:
Alpha-D-galactose 1-phosphate + H(2)O = D-galactose + phosphate. 
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate. 

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol monophosphatase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 30.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29218 (Residues: 2-277; Coverage: 100%)
Gene names: IMPA, IMPA1
Sequence domains: Inositol monophosphatase family
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE M18XH
Spacegroup: P3221
Unit cell:
a: 86.37Å b: 86.37Å c: 153.795Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.153 0.153 0.189
Expression system: Escherichia coli