PDBe 1a6z

X-ray diffraction
2.6Å resolution

HFE (HUMAN) HEMOCHROMATOSIS PROTEIN

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hereditary hemochromatosis protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 275 amino acids
Theoretical weight: 32.34 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q30201 (Residues: 23-297; Coverage: 84%)
Gene names: HFE, HLAH
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, D
Molecule details ›
Chains: B, D
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 68.8Å b: 100.1Å c: 147.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.233 0.277
Expression system: Cricetulus griseus