PDBe 1a6a

X-ray diffraction
2.75Å resolution

THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
hetero hexamer
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class II histocompatibility antigen gamma chain Chain: C
Molecule details ›
Chain: C
Length: 15 amino acids
Theoretical weight: 1.68 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P04233 (Residues: 103-117; Coverage: 5%)
Gene names: CD74, DHLAG
HLA class II histocompatibility antigen, DR alpha chain Chain: A
Molecule details ›
Chain: A
Length: 176 amino acids
Theoretical weight: 20.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01903 (Residues: 30-205; Coverage: 77%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains: Immunoglobulin C1-set domain
Structure domains:
HLA class II histocompatibility antigen, DRB1-3 chain Chain: B
Molecule details ›
Chain: B
Length: 187 amino acids
Theoretical weight: 21.94 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01912 (Residues: 34-220; Coverage: 79%)
Gene name: HLA-DRB1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P3212
Unit cell:
a: 78.45Å b: 78.45Å c: 159.1Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.246 0.325