PDBe 1a22

X-ray diffraction
2.6Å resolution

HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Somatotropin Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 22.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01241 (Residues: 27-217; Coverage: 100%)
Gene name: GH1
Structure domains: Growth Hormone; Chain: A;
Growth hormone-binding protein Chain: B
Molecule details ›
Chain: B
Length: 238 amino acids
Theoretical weight: 27.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10912 (Residues: 19-256; Coverage: 38%)
Gene name: GHR
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P43212
Unit cell:
a: 67.7Å b: 67.7Å c: 228Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 not available
Expression system: Escherichia coli