EMDB EMD-9230

Single particle reconstruction
3.2Å resolution

Phosphorylated, ATP-bound human cystic fibrosis transmembrane conductance regulator (CFTR)

Map released:
Overview of EMD-9230
Source organism: Homo sapiens [9606]
Fitted atomic model: 6msm
Primary publication:
Molecular structure of the ATP-bound, phosphorylated human CFTR
Zhang Z, Liu F, Chen J
Proc.Natl.Acad.Sci.Usa - (2018)

Function and Biology Details

Sample name: human cystic fibrosis transmembrane conductance regulator (CFTR)
Ligands: MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL
Proteins: human cystic fibrosis transmembrane conductance regulator (CFTR), Cystic fibrosis transmembrane conductance regulator, Piece of Molecule-1

Experimental Information Details

Resolution: 3.2Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)