EMDB EMD-8922

Single particle reconstruction
3.8Å resolution

Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (Whole map)

Map released:
Overview of EMD-8922
Source organism: Rattus norvegicus [10116]
Fitted atomic model: 6dw0
Related EM entry by publication: EMD-8923
Primary publication:
Cryo-EM structure of the benzodiazepine-sensitive alpha 1 beta 1 gamma 2S tri-heteromeric GABAAreceptor in complex with GABA.
Phulera S, Zhu H, Yu J, Claxton DP, Yoder N, Yoshioka C, Gouaux E
Elife 7 - (2018)
PMID: 30044221

Function and Biology Details

Sample name: Triheteromeric alpha1-beta1-gamma2 GABAA receptor
Ligands: N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ALPHA-D-MANNOSE, GAMMA-AMINO-BUTANOIC ACID
Proteins: Triheteromeric alpha1-beta1-gamma2 GABAA receptor, Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit beta-1,Gamma-aminobutyric acid receptor subunit beta-1

Experimental Information Details

Resolution: 3.8Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Microscope: FEI TITAN KRIOS
Detector: FEI FALCON III (4k x 4k)