EMDB EMD-8902

Helical reconstruction
3.17Å resolution

Cryo-EM Structures of ASC and NLRC4 CARD Filaments Reveal a Unified Mechanism of Nucleation and Activation of Caspase-1

Map released:
Last modified:
Overview of EMD-8902
Source organism: Homo sapiens [9606]
Fitted atomic model: 6drn
Related EM entry by publication: EMD-8903
Primary publication:
Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1.
Li Y, Fu TM, Lu A, Witt K, Ruan J, Shen C, Wu H
Proc. Natl. Acad. Sci. U.S.A. - (2018)
PMID: 30279182

Function and Biology Details

Sample name: Caspase recruitment domain of Apoptosis-associated speck-like protein containing a CARD
Cellular component: Caspase recruitment domain of Apoptosis-associated speck-like protein containing a CARD
Protein: Apoptosis-associated speck-like protein containing a CARD

Experimental Information Details

Resolution: 3.17Å
Resolution method: FSC 0.143 CUT-OFF
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)