EMDB EMD-8573

Single particle reconstruction
28.1Å resolution

HIV-1 CH505 Transmitted Founder SOSIP.664 Env trimer in Complex with the DH576 Fab from the RV305 Trial

Map released:
Overview of EMD-8573
Source organism: Homo sapiens [9606]
Primary publication:
Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.
Easterhoff D, Moody MA, Fera D, Cheng H, Ackerman M, Wiehe K, Saunders KO, Pollara J, Vandergrift N, Parks R, Kim J, Michael NL, O'Connell RJ, Excler JL, Robb ML, Vasan S, Rerks-Ngarm S, Kaewkungwal J, Pitisuttithum P, Nitayaphan S, Sinangil F, Tartaglia J, Phogat S, Kepler TB, Alam SM, Liao HX, Ferrari G, Seaman MS, Montefiori DC, Tomaras GD, Harrison SC, Haynes BF
PLoS Pathog. 13 e1006182-e1006182 (2017)
PMID: 28235027

Function and Biology Details

Sample name: HIV-1 CH505 Transmitted Founder SOSIP.664 Env trimer in Complex with the DH576 Fab from the RV305 Trial
Proteins: HIV-1 CH505 Transmitted Founder SOSIP.664 Env trimer in Complex with the DH576 Fab from the RV305 Trial, CH505 Transmitted Founder Envelope, DH576 Fab, HIV Envelope, DH576 Fab Light Chain, DH576 Fab Heavy Chain

Experimental Information Details

Resolution: 28.1Å
Resolution method: FSC 0.5 CUT-OFF
Applied symmetry: C3
Reconstruction software: EMAN2
Microscope: FEI TECNAI 12
Detector: GATAN ULTRASCAN 4000 (4k x 4k)