EMD-8014
Body region of the U4/U6.U5 tri-snRNP
EMD-8014
Single-particle3.6 Å
Deposition: 15/12/2015
Map released: 27/01/2016
Last modified: 02/10/2019
Name: Body region of the U4/U6.U5 tri-snRNP complex
Body region of the U4/U6.U5 tri-snRNP complex
Name: Natural source [1]
Organism: Saccharomyces cerevisiae
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 500 kDa | - |
U4 snRNA, 5' region, nucleotides 1-67
Number of copies: 1
Details: U4 snRNA 5' region, nucleotides 1-67.
Name: Number of copies: 1
Details: U4 snRNA 5' region, nucleotides 1-67.
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 21 kDa | - |
U6 snRNA
Number of copies: 1
Name: Number of copies: 1
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 35 kDa | - |
U5 snRNA
Number of copies: 1
Name: Number of copies: 1
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 68 kDa | - |
unknown protein
Number of copies: 1
Details: Clear helical regions were built as poly(Ala) but could not be assigned to a specific protein.
Name: Number of copies: 1
Details: Clear helical regions were built as poly(Ala) but could not be assigned to a specific protein.
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 6 kDa | - |
Pre-mRNA-splicing factor 8
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [20]
Biological process:
mRNA splicing, via spliceosome spliceosomal snRNP assembly mRNA 5'-splice site recognition mRNA 3'-splice site recognition spliceosomal tri-snRNP complex assembly generation of catalytic spliceosome for second transesterification step
Molecular function:
metallopeptidase activity U6 snRNA binding mRNA binding pre-mRNA intronic binding isopeptidase activity U1 snRNA binding U2 snRNA binding U5 snRNA binding
Cellular location:
cytoplasm spliceosomal complex catalytic step 2 spliceosome U5 snRNP nucleus U4/U6 x U5 tri-snRNP complex
mRNA splicing, via spliceosome spliceosomal snRNP assembly mRNA 5'-splice site recognition mRNA 3'-splice site recognition spliceosomal tri-snRNP complex assembly generation of catalytic spliceosome for second transesterification step
Molecular function:
metallopeptidase activity U6 snRNA binding mRNA binding pre-mRNA intronic binding isopeptidase activity U1 snRNA binding U2 snRNA binding U5 snRNA binding
Cellular location:
cytoplasm spliceosomal complex catalytic step 2 spliceosome U5 snRNP nucleus U4/U6 x U5 tri-snRNP complex
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 279 kDa | - |
U4/U6 small nuclear ribonucleoprotein PRP4
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
spliceosomal complex assembly mRNA splicing, via spliceosome snoRNA splicing spliceosomal conformational changes to generate catalytic conformation
Molecular function:
U6 snRNA binding U4 snRNA binding
Cellular location:
nucleus U4 snRNP U4/U6 snRNP U4/U6 x U5 tri-snRNP complex spliceosomal complex
spliceosomal complex assembly mRNA splicing, via spliceosome snoRNA splicing spliceosomal conformational changes to generate catalytic conformation
Molecular function:
U6 snRNA binding U4 snRNA binding
Cellular location:
nucleus U4 snRNP U4/U6 snRNP U4/U6 x U5 tri-snRNP complex spliceosomal complex
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 52 kDa | - |
Pre-mRNA-splicing factor 6
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
spliceosomal tri-snRNP complex assembly mRNA splicing, via spliceosome
Cellular location:
nucleus U5 snRNP spliceosomal complex U4/U6 snRNP U4/U6 x U5 tri-snRNP complex catalytic step 2 spliceosome
spliceosomal tri-snRNP complex assembly mRNA splicing, via spliceosome
Cellular location:
nucleus U5 snRNP spliceosomal complex U4/U6 snRNP U4/U6 x U5 tri-snRNP complex catalytic step 2 spliceosome
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 104 kDa | - |
Spliceosomal protein DIB1
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [5]
Biological process:
mRNA splicing, via spliceosome
Cellular location:
U5 snRNP nucleus U4/U6 x U5 tri-snRNP complex spliceosomal complex
mRNA splicing, via spliceosome
Cellular location:
U5 snRNP nucleus U4/U6 x U5 tri-snRNP complex spliceosomal complex
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 16 kDa | - |
Pre-mRNA-processing factor 31
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
mRNA splicing, via spliceosome spliceosomal snRNP assembly spliceosomal tri-snRNP complex assembly
Molecular function:
RNA binding
Cellular location:
U4/U6 snRNP nucleus spliceosomal complex mitochondrion U4 snRNP precatalytic spliceosome spliceosomal tri-snRNP complex U4/U6 x U5 tri-snRNP complex
mRNA splicing, via spliceosome spliceosomal snRNP assembly spliceosomal tri-snRNP complex assembly
Molecular function:
RNA binding
Cellular location:
U4/U6 snRNP nucleus spliceosomal complex mitochondrion U4 snRNP precatalytic spliceosome spliceosomal tri-snRNP complex U4/U6 x U5 tri-snRNP complex
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 56 kDa | - |
U4/U6 small nuclear ribonucleoprotein PRP3
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
spliceosomal complex assembly mRNA splicing, via spliceosome spliceosomal snRNP assembly
Cellular location:
U4 snRNP U4/U6 snRNP nucleus U4/U6 x U5 tri-snRNP complex spliceosomal complex
spliceosomal complex assembly mRNA splicing, via spliceosome spliceosomal snRNP assembly
Cellular location:
U4 snRNP U4/U6 snRNP nucleus U4/U6 x U5 tri-snRNP complex spliceosomal complex
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 55 kDa | - |
13 kDa ribonucleoprotein-associated protein
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [22]
Biological process:
spliceosomal complex assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of RNA binding maturation of LSU-rRNA maturation of SSU-rRNA box C/D RNA 3'-end processing snoRNA guided rRNA 2'-O-methylation mRNA splicing, via spliceosome
Molecular function:
U3 snoRNA binding RNA binding U4 snRNA binding
Cellular location:
cytosolic large ribosomal subunit U4 snRNP spliceosomal complex U4/U6 snRNP nucleus nucleoplasm box C/D RNP complex precatalytic spliceosome small-subunit processome U4/U6 x U5 tri-snRNP complex nucleolus
spliceosomal complex assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of RNA binding maturation of LSU-rRNA maturation of SSU-rRNA box C/D RNA 3'-end processing snoRNA guided rRNA 2'-O-methylation mRNA splicing, via spliceosome
Molecular function:
U3 snoRNA binding RNA binding U4 snRNA binding
Cellular location:
cytosolic large ribosomal subunit U4 snRNP spliceosomal complex U4/U6 snRNP nucleus nucleoplasm box C/D RNP complex precatalytic spliceosome small-subunit processome U4/U6 x U5 tri-snRNP complex nucleolus
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 13 kDa | - |
Pre-mRNA-splicing helicase BRR2
EC number: 3.6.4.13
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Name: EC number: 3.6.4.13
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
mRNA splicing, via spliceosome spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
Molecular function:
RNA helicase activity nucleic acid binding identical protein binding ATP binding ATP hydrolysis activity
Cellular location:
spliceosomal complex U5 snRNP nucleus U4/U6 x U5 tri-snRNP complex
mRNA splicing, via spliceosome spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
Molecular function:
RNA helicase activity nucleic acid binding identical protein binding ATP binding ATP hydrolysis activity
Cellular location:
spliceosomal complex U5 snRNP nucleus U4/U6 x U5 tri-snRNP complex
Natural source
Organism: Baker's yeast
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 246 kDa | - |