EMDB EMD-7964

Single particle reconstruction
4.1Å resolution

Cryo-EM structure of human Ptch1 with three mutations L282Q/T500F/P504L

Map released:
Overview of EMD-7964
Source organism: Homo sapiens [9606]
Fitted atomic model: 6dmo
Related EM entry by publication: EMD-7963, EMD-7968
Primary publication:
Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Gong X, Qian H, Cao P, Zhao X, Zhou Q, Lei J, Yan N
Science - (2018)
PMID: 29954986

Function and Biology Details

Sample name: Patch1 with L282Q/T500F/P504L mutations
Cellular component: Patch1 with L282Q/T500F/P504L mutations
Ligand: N-ACETYL-D-GLUCOSAMINE
Protein: Protein patched homolog 1

Experimental Information Details

Resolution: 4.1Å
Resolution method: FSC 0.143 CUT-OFF
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)