EMDB EMD-7868

Single particle reconstruction
3.5Å resolution

Mu Opioid Receptor-Gi Protein Complex

Map released:
Last modified:
Overview of EMD-7868
Source organisms:
Fitted atomic model: 6dde
Related EM entry by publication: EMD-7869
Primary publication:
Structure of the mu-opioid receptor-Giprotein complex.
Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK
Nature 558 547-552 (2018)
PMID: 29899455

Function and Biology Details

Sample name: Ternary complex of DAMGO-activated Mu-type opioid receptor with heterotrimeric Gi, further stabilized by addition of Scfv-16
Proteins: Ternary complex of DAMGO-activated Mu-type opioid receptor with heterotrimeric Gi, further stabilized by addition of Scfv-16, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, scFv16, Mu-type opioid receptor, DAMGO

Experimental Information Details

Resolution: 3.5Å
Resolution method: FSC 0.143 CUT-OFF
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)