EMDB EMD-7462

Single particle reconstruction
4.3Å resolution

Insulin Receptor ectodomain in complex with two insulin molecules

Map released:
Last modified:
Overview of EMD-7462
Source organisms:
Fitted atomic model: 6ce9
Related EM entry by publication: EMD-7461, EMD-7463
Primary publication:
Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Scapin G, Dandey VP, Zhang Z, Prosise W, Hruza A, Kelly T, Mayhood T, Strickland C, Potter CS, Carragher B
Nature 556 122-125 (2018)
PMID: 29512653

Function and Biology Details

Sample name: Insulin Receptor Ectodomain in complex with two insulin molecules
Ligands: N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, BETA-D-MANNOSE
Proteins: Insulin Receptor Ectodomain in complex with two insulin molecules, Insulin receptor, Insulin receptor subunit alpha, Insulin A chain, Insulin B chain, Insulin receptor, Insulin receptor, Insulin A chain, Insulin B chain

Experimental Information Details

Resolution: 4.3Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C2
Reconstruction software: cryoSPARC
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 QUANTUM (4k x 4k)