EMDB EMD-7442

Single particle reconstruction
2.8Å resolution

Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens

Map released:
Overview of EMD-7442
Source organism: Homo sapiens [9606]
Fitted atomic model: 6caj
Related EM entry by publication: EMD-7443, EMD-7444
Primary publication:
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P
Science 359 - (2018)
PMID: 29599213

Function and Biology Details

Sample name: Translation initiation factor eIF-2B decamer
Ligand: 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide
Proteins: Translation initiation factor eIF-2B decamer, Translation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF-2B subunit gamma, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta

Experimental Information Details

Resolution: 2.8Å
Resolution method: FSC 0.5 CUT-OFF
Applied symmetry: C2
Reconstruction software: FREALIGN
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 (4k x 4k)