EMDB EMD-7041

Single particle reconstruction
3.7Å resolution

Cryo-EM structure of human insulin degrading enzyme in complex with insulin

Map released:
Last modified:
Overview of EMD-7041
Source organism: Homo sapiens [9606]
Fitted atomic model: 6b3q
Related EM entries by publication: EMD-7062, EMD-7065, EMD-7066, EMD-7090, EMD-7091, EMD-7092, EMD-7093
Primary publication:
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
Elife 7 - (2018)
PMID: 29596046

Function and Biology Details

Sample name: Insulin degrading enzyme/Insulin
Proteins: Insulin degrading enzyme/Insulin, Insulin-degrading enzyme, Insulin

Experimental Information Details

Resolution: 3.7Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)