EMDB EMD-6997

Single particle reconstruction
2.6Å resolution

Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with tetrodotoxin and Dc1a

Map released:
Overview of EMD-6997
Source organisms:
Fitted atomic model: 6a95
Related EM entry by publication: EMD-6995, EMD-6996
Primary publication:
Structural basis for the modulation of voltage-gated sodium channels by animal toxins.
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science - (2018)
PMID: 30049784

Function and Biology Details

Sample name: complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with saxitoxin and Dc1a
Ligands: N-ACETYL-D-GLUCOSAMINE, (1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name), SODIUM ION, water
Proteins: complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with saxitoxin and Dc1a, voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana, Dc1a, Sodium channel protein PaFPC1, Mu-diguetoxin-Dc1a

Experimental Information Details

Resolution: 2.6Å
Resolution method: FSC 0.143 CUT-OFF
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 QUANTUM (4k x 4k)