EMDB EMD-6996

Single particle reconstruction
3.2Å resolution

Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with saxitoxin and Dc1a

Map released:
Overview of EMD-6996
Source organisms:
Fitted atomic model: 6a91
Related EM entry by publication: EMD-6995, EMD-6997
Primary publication:
Structural basis for the modulation of voltage-gated sodium channels by animal toxins.
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science - (2018)
PMID: 30049784

Function and Biology Details

Sample name: complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with saxitoxin and Dc1a
Ligands: N-ACETYL-D-GLUCOSAMINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate, water
Proteins: complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with saxitoxin and Dc1a, voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana, Dc1a, Sodium channel protein PaFPC1, Mu-diguetoxin-Dc1a

Experimental Information Details

Resolution: 3.2Å
Resolution method: FSC 0.143 CUT-OFF
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 QUANTUM (4k x 4k)