EMD-6733
Cryo-EM Structure of the ATP-bound VPS4 mutant-E233Q hexamer (masked)
EMD-6733
Single-particle3.9 Å
Deposition: 15/05/2017
Map released: 09/08/2017
Last modified: 27/03/2024
Name: Vps4-E233Q hexamer
Summary:
Name:
Vacuolar protein sorting-associated protein 4
Number of copies: 6
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Name: Number of copies: 6
UniProtKB UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [34]
Biological process:
reticulophagy intralumenal vesicle formation multivesicular body sorting pathway autophagosome maturation late endosome to vacuole transport via multivesicular body sorting pathway membrane fission sterol metabolic process autophagy protein transport macroautophagy negative regulation of cell death late endosome to vacuole transport protein retention in Golgi apparatus vacuole organization late endosome to lysosome transport via multivesicular body sorting pathway multivesicular body assembly endosomal transport nucleus organization nuclear membrane reassembly midbody abscission plasma membrane repair
Molecular function:
ATP binding ATP hydrolysis activity protein homodimerization activity identical protein binding
Cellular location:
midbody nuclear pore ATPase complex endoplasmic reticulum ESCRT IV complex endosome plasma membrane cytoplasm membrane
reticulophagy intralumenal vesicle formation multivesicular body sorting pathway autophagosome maturation late endosome to vacuole transport via multivesicular body sorting pathway membrane fission sterol metabolic process autophagy protein transport macroautophagy negative regulation of cell death late endosome to vacuole transport protein retention in Golgi apparatus vacuole organization late endosome to lysosome transport via multivesicular body sorting pathway multivesicular body assembly endosomal transport nucleus organization nuclear membrane reassembly midbody abscission plasma membrane repair
Molecular function:
ATP binding ATP hydrolysis activity protein homodimerization activity identical protein binding
Cellular location:
midbody nuclear pore ATPase complex endoplasmic reticulum ESCRT IV complex endosome plasma membrane cytoplasm membrane
Natural source
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 48 kDa | - |
Recombinant Expression
Organism | Strain | Cell | Plasmid |
---|---|---|---|
Escherichia coli | - | - | - |
ADENOSINE-5'-TRIPHOSPHATE
HET code: ATP
Number of copies: 5
ChEMBL ChEBI DrugBank
Name: HET code: ATP
Number of copies: 5
ChEMBL ChEBI DrugBank
Molecular weight
Experimental | Theoretical | Method |
---|---|---|
- | 507 Da | - |