EMD-5606 Function and Biology

Substrate-specific structural rearrangements of human Dicer

Single particle reconstruction
26Å resolution
Overview of EMD-5606
Sample name: Human Dicer-PACT heterodimer in open conformation
Number of unique components: 2
Oligomeric state: monomer
Theoretical weight (MDa): 0.26

Endoribonuclease Dicer [Homo sapiens]

Protein type
Name: Endoribonuclease Dicer
Alternative name: Dicer, Helicase with RNase motif
Theoretical weight (MDa): 0.22
Number of copies: 1
Oligomeric state: monomer
UniProt: Q9UPY3
GO: GO:0031054
InterPro: IPR000999, IPR003100, IPR001650, IPR014001, IPR014720, IPR001159, IPR011545, IPR005034

Interferon-inducible double stranded RNA-dependent protein kinase activator A [Homo sapiens]

Protein type
Name: Interferon-inducible double stranded RNA-dependent protein kinase activator A
Alternative name: PACT
Theoretical weight (MDa): 0.034
Number of copies: 1
Oligomeric state: monomer
UniProt: O75569
GO: GO:0003725
InterPro: IPR001159, IPR014720