EMDB EMD-4390

Single particle reconstruction
4.11Å resolution

Cryo-EM structure of the adenosine A2A receptor bound to a miniGs heterotrimer

Map released:
Overview of EMD-4390
Source organisms:
Fitted atomic model: 6gdg
Primary publication:
Cryo-EM structure of the adenosine A2Areceptor coupled to an engineered heterotrimeric G protein.
Garcia-Nafria J, Lee Y, Bai X, Carpenter B, Tate CG
Elife 7 - (2018)
PMID: 29726815

Function and Biology Details

Sample name: Adenosine A2A receptor bound to miniGs heterotrimer
Ligand: N-ETHYL-5'-CARBOXAMIDO ADENOSINE
Proteins: Adenosine A2A receptor bound to miniGs heterotrimer, Adenosine receptor A2a, miniGs heterotrimer, nanobody Nb35, TrxA,Adenosine receptor A2a, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, nanobody Nb35

Experimental Information Details

Resolution: 4.11Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: OTHER