EMD-24953

Helical reconstruction
2.9 Å
EMD-24953
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Deposition: 23/09/2021
Map released: 09/03/2022
Last modified: 25/05/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-24953
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7saq summary report (pdf.gz) Map and 7saq FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1

EMD-24953

Helical reconstruction
2.9 Å
EMD-24953
3D View Gallery
Deposition: 23/09/2021
Map released: 09/03/2022
Last modified: 25/05/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Human
Sample: TMEM106B fibrils, polymorph 1
Fitted models: 7saq

Deposition Authors: Cao Q , Jiang Y , Sawaya MR , Eisenberg DS
Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Jiang YX , Cao Q , Sawaya MR , Abskharon R, Ge P , DeTure M, Dickson DW , Fu JY , Ogorzalek Loo RR, Loo JA , Eisenberg DS
(2022) Nature , 605 , 304 - 309
PUBMED: 35344984
DOI: doi:10.1038/s41586-022-04670-9
ISSN: 1476-4687
ASTM: NATUAS