EMDB EMD-20528

Single particle reconstruction
3.65Å resolution

Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and repaglinide

Map released:
Overview of EMD-20528
Source organisms:
Fitted atomic model: 6pz9
Related EM entries by publication: EMD-20530, EMD-20533, EMD-20534, EMD-20535
Primary publication:
Mechanism of pharmacochaperoning in a mammalian KATPchannel revealed by cryo-EM.
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
Elife 8 - (2019)
PMID: 31343405

Function and Biology Details

Sample name: KATP-RPG-ATP
Ligands: Repaglinide, ADENOSINE-5'-TRIPHOSPHATE
Proteins: KATP-RPG-ATP, SUR1, KATP, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11

Experimental Information Details

Resolution: 3.65Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Microscope: FEI TITAN KRIOS
Detector: FEI FALCON III (4k x 4k)