EMDB EMD-0345

Single particle reconstruction
4.0Å resolution

Metabotropic Glutamate Receptor 5 bound to L-quisqualate and Nb43

Map released:
Last modified:
Overview of EMD-0345
Source organisms:
Fitted atomic model: 6n51
Related EM entry by publication: EMD-0346, EMD-0347
Primary publication:
Structural insights into the activation of metabotropic glutamate receptors.
Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laermans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK
Nature 566 79-84 (2019)
PMID: 30675062

Function and Biology Details

Sample name: Complex between metabotropic glutamate receptor 5 bound to L-quisqualate and Nb43
Ligands: N-ACETYL-D-GLUCOSAMINE, (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID
Proteins: Complex between metabotropic glutamate receptor 5 bound to L-quisqualate and Nb43, Metabotropic glutamate receptor 5, Nanobody 43

Experimental Information Details

Resolution: 4.0Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C2
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)