EMDB EMD-0259

Helical reconstruction
3.2Å resolution

Paired helical filament from sporadic Alzheimer's disease brain

Map released:
Overview of EMD-0259
Source organism: Human [9606]
Fitted atomic model: 6hre
Related EM entry by publication: EMD-0260
Primary publication:
Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Falcon B, Zhang W, Schweighauser M, Murzin AG, Vidal R, Garringer HJ, Ghetti B, Scheres SHW, Goedert M
Acta Neuropathol. - (2018)
PMID: 30276465

Function and Biology Details

Sample name: Tau filaments extracted from the frontotemporal cortex of a patient with sporadic Alzheimer's disease
Cellular component: Tau filaments extracted from the frontotemporal cortex of a patient with sporadic Alzheimer's disease
Protein: Microtubule-associated protein tau

Experimental Information Details

Resolution: 3.2Å
Resolution method: FSC 0.143 CUT-OFF
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 QUANTUM (4k x 4k)