EMDB EMD-0228

Single particle reconstruction
4.5Å resolution

Mouse serotonin 5-HT3 receptor, tropisetron-bound, T conformation

Map released:
Overview of EMD-0228
Source organism: Mus musculus [10090]
Fitted atomic model: 6his
Related EM entries by publication: EMD-0225, EMD-0226, EMD-0227
Primary publication:
Conformational transitions of the serotonin 5-HT3 receptor
Polovinkin L, Hassaine G, Perot J, Neumann E, Jensen AA, Lefebvre SN, Corringer PJ, Neyton J, Chipot C, Dehez F, Schoehn G, Nury H
Nature - (2018)

Function and Biology Details

Sample name: 5-HT3 receptor, serotonin-bound
Ligands: N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-INDOLE-3-CARBOXYLATE
Proteins: 5-HT3 receptor, serotonin-bound, 5-hydroxytryptamine receptor 3A

Experimental Information Details

Resolution: 4.5Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C5
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)