EMDB EMD-0077

Helical reconstruction
3.2Å resolution

Narrow Pick Filament from Pick's disease brain

Map released:
Last modified:
Overview of EMD-0077
Source organism: Human [9606]
Fitted atomic model: 6gx5
Related EM entry by publication: EMD-0078
Primary publication:
Structures of filaments from Pick's disease reveal a novel tau protein fold.
Falcon B, Zhang W, Murzin AG, Murshudov G, Garringer HJ, Vidal R, Crowther RA, Ghetti B, Scheres SHW, Goedert M
Nature 561 137-140 (2018)
PMID: 30158706

Function and Biology Details

Sample name: Tau filaments extracted from the frontotemporal cortex of a patient with Pick's disease
Cellular component: Tau filaments extracted from the frontotemporal cortex of a patient with Pick's disease
Protein: Microtubule-associated protein tau

Experimental Information Details

Resolution: 3.2Å
Resolution method: FSC 0.143 CUT-OFF
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 QUANTUM (4k x 4k)