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Cartoon diagram of a HindIII dimer with bound DNA

PDB entries 3wvg3wvh3wvi3wvk and 3wvp

HindIII is a very commonly used restriction endonuclease in molecular biology, recognising the palindromic DNA sequence AACGTT and cleaving between the two adenosine residues. Metal ions are required at the active site for the enzyme to function and previous studies have shown two are present at the active site. It has been unclear however whether one or both ions were needed for catalysis, but these structures shed light on this.

The work is descibed by Kawamura et al. in Acta Cryst D. DOI:10.1107/S1399004714025188

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Westbrook JD, Shao C, Feng Z, Zhuravleva M, Velankar S, Young J.
Bioinformatics Volume 31 (2015) p.1274-1278

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Seixas JD, Santos MF, Mukhopadhyay A, Coelho AC, Reis PM, Veiros LF, Marques AR, Penacho N, Gonçalves AM, Romão MJ, Bernardes GJ, Santos-Silva T, Romão CC.
Dalton Trans Volume 44 (2015) p.5058-5075

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