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Peptide (shown as sticks) bound to a chicken MHC

9th May 2015

MHC molecules, which signal to the immune system that a cell is infected, are able to bind to different peptides derived from the infecting organism. While some MHCs can bind many different peptides, others show greater selectivity. In a recent paper in eLife, Chappell et al have solved the structures of seven chicken MHCs bound to different peptides to investigate the molecular nature of this different binding specificity.

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Publications

Salavert J, Tomás A, Tárraga J, Medina I, Dopazo J, Blanquer I.
BMC Bioinformatics Volume 16 (2015) p.18

Lewis TE, Sillitoe I, Andreeva A, Blundell TL, Buchan DW, Chothia C, Cozzetto D, Dana JM, Filippis I, Gough J, Jones DT, Kelley LA, Kleywegt GJ, Minneci F, Mistry J, Murzin AG, Ochoa-Montaño B, Oates ME, Punta M, Rackham OJ, Stahlhacke J, Sternberg MJ, Velankar S, Orengo C.
Nucleic Acids Res Volume 43 (2015) p.d382-6

Westbrook JD, Shao C, Feng Z, Zhuravleva M, Velankar S, Young J.
Bioinformatics Volume 31 (2015) p.1274-1278

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