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Schematic diagram of Solanezumab bound to amyloid beta peptide

23rd July 2015

Solanezumab, an antibody which may slow the progresion of Alzheimer's disease, recognizes a central portion of amyloid beta. Its structure reveals how.



Gutmanas A, Adams PD, Bardiaux B, Berman HM, Case DA, Fogh RH, Güntert P, Hendrickx PM, Herrmann T, Kleywegt GJ, Kobayashi N, Lange OF, Markley JL, Montelione GT, Nilges M, Ragan TJ, Schwieters CD, Tejero R, Ulrich EL, Velankar S, Vranken WF, Wedell JR, Westbrook J, Wishart DS, Vuister GW.
Nat Struct Mol Biol Volume 22 (2015) p.433-434

Meldal BH, Forner-Martinez O, Costanzo MC, Dana J, Demeter J, Dumousseau M, Dwight SS, Gaulton A, Licata L, Melidoni AN, Ricard-Blum S, Roechert B, Skyzypek MS, Tiwari M, Velankar S, Wong ED, Hermjakob H, Orchard S.
Nucleic Acids Res Volume 43 (2015) p.d479-84

Westbrook JD, Shao C, Feng Z, Zhuravleva M, Velankar S, Young J.
Bioinformatics Volume 31 (2015) p.1274-1278

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