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CRYSTAL STRUCTURE OF PORCINE CATHEPSIN H DETERMINED AT 2.1 ANGSTROM RESOLUTION: LOCATION OF THE MINI-CHAIN C-TERMINAL CARBOXYL GROUP DEFINES CATHEPSIN H AMINOPEPTIDASE FUNCTION

X-ray diffraction
2.1Å resolution
PDB entry 8pch coloured by chain, front view.
PDB entry 8pch coloured by chain, side view.
PDB entry 8pch coloured by chain, top view.
Source organism: Sus scrofa
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cathepsin H mini chain
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Multimeric state: hetero dimer
Accessible surface area: 10088.44 Å2
Buried surface area: 2129.73 Å2
Dissociation area: 565.26 Å2
Dissociation energy (ΔGdiss): -1.51 kcal/mol
Dissociation entropy (TΔSdiss): 6.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-129216

Macromolecules

Cathepsin H
Chain: A
Length: 220 amino acids
Theoretical weight: 24.33 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O46427 (Residues: 116-335; Coverage: 70%)
Gene name: CTSH
Pfam: Papain family cysteine protease
InterPro:
CATH: Cysteine proteinases
SCOP: Papain-like
Cathepsin H in PDB entry 8pch, assembly 1, front view.
Cathepsin H in PDB entry 8pch, assembly 1, side view.
Cathepsin H in PDB entry 8pch, assembly 1, top view.
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Cathepsin H mini chain
Chain: P
Length: 8 amino acids
Theoretical weight: 849 Da
Source organism: Sus scrofa
UniProt:
  • Canonical: O46427 (Residues: 98-105; Coverage: 3%)
Gene name: CTSH
SCOP: Papain-like
Cathepsin H mini chain in PDB entry 8pch, assembly 1, front view.
Cathepsin H mini chain in PDB entry 8pch, assembly 1, side view.
Cathepsin H mini chain in PDB entry 8pch, assembly 1, top view.
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